COAGULATION FACTOR

Pronunciation (US):

(GB):

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 Dictionary entry overview: What does coagulation factor mean? 

• COAGULATION FACTOR (noun)
  The noun COAGULATION FACTOR has 1 sense:

1. any of the factors in the blood whose actions are essential for blood coagulation

  Familiarity information: COAGULATION FACTOR used as a noun is very rare.

 Dictionary entry details 

• COAGULATION FACTOR (noun)

Sense 1

Meaning:

Any of the factors in the blood whose actions are essential for blood coagulation

Classified under:

Nouns denoting substances

Synonyms:

clotting factor; coagulation factor

Hypernyms ("coagulation factor" is a kind of...):

plasma protein (any of the proteins in blood plasma)

Hyponyms (each of the following is a kind of "coagulation factor"):

factor I; fibrinogen (a protein present in blood plasma; converts to fibrin when blood clots)

factor II; prothrombin (a protein in blood plasma that is the inactive precursor of thrombin)

factor III; thrombokinase; thromboplastin (an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot)

calcium ion; factor IV (ion of calcium; a factor in the clotting of blood)

accelerator factor; factor V; proaccelerin; prothrombin accelerator (a coagulation factor)

cothromboplastin; factor VII; proconvertin; stable factor (a coagulation factor formed in the kidney under the influence of vitamin K)

antihaemophilic factor; antihaemophilic globulin; antihemophilic factor; antihemophilic globulin; factor VIII; Hemofil (a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A)

Christmas factor; factor IX (coagulation factor whose absence is associated with hemophilia B)

factor X; prothrombinase (coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors)

factor XI; plasma thromboplastin antecedent (coagulation factor whose deficiency results in a hemorrhagic tendency)

factor XII; Hageman factor (coagulation factor whose deficiency results in prolongation of clotting time of venous blood)

factor XIII; fibrinase (in the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot)

 Context examples 

There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.

(Disseminated Intravascular Coagulation, NCI Thesaurus/CTCAE)

The tosylate salt form of edoxaban, an orally active inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity.

(Edoxaban Tosylate, NCI Thesaurus)

This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage.

(Disseminated Intravascular Coagulation, NCI Thesaurus)

Hemophilia B is caused by mutations in the gene for coagulation factor IX, a protein that helps blood to clot.

(Gene Therapy Used to Treat Hemophilia, NIH)

Coagulation factor XII ( 615 aa, ~68 kDa) is encoded by the human F12 gene.

(Coagulation Factor XII, NCI Thesaurus)

This allele, which encodes coagulation factor XII protein, plays a role in coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.

(F12 wt Allele, NCI Thesaurus)

This allele, which encodes coagulation factor V Leiden protein, is involved in hypercoagulability due to resistance to degradation by activated protein C.

(F5 Leiden Allele, NCI Thesaurus)

The vitamins K are essential for blood coagulation as it is necessary for the hepatic synthesis of the coagulation factors II, VII, IX, and X; deficiency results in a bleeding diathesis.

(Phytonadione, NCI Thesaurus)

The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation.

(Platelet Amyloid Precursor Protein Pathway, NCI Thesaurus/BIOCARTA)

A deficiency or abnormality of a blood coagulation factor characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage, Hemophilia is typically a hereditary disorder but, rarely, may be acquired.

(Hemophilia, NCI Thesaurus)