CHROMOSOMAL ABERRATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does chromosomal aberration mean? 

• CHROMOSOMAL ABERRATION (noun)
  The noun CHROMOSOMAL ABERRATION has 1 sense:

1. any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities

  Familiarity information: CHROMOSOMAL ABERRATION used as a noun is very rare.

 Dictionary entry details 

• CHROMOSOMAL ABERRATION (noun)

Sense 1

Meaning:

Any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities

Classified under:

Nouns denoting stable states of affairs

Synonyms:

chromosomal aberration; chromosomal anomaly; chromosonal disorder; chrosomal abnormality

Hypernyms ("chromosomal aberration" is a kind of...):

aberrance; aberrancy; aberration; deviance (a state or condition markedly different from the norm)

Hyponyms (each of the following is a kind of "chromosomal aberration"):

monosomy (chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number)

trisomy (chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell)

sex-linked disorder (any disease or abnormality that is determined by the sex hormones)

 Context examples 

Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome.

(CLTCL1 wt Allele, NCI Thesaurus)

It allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations with high sensitivity and specificity.

(Chromosome Painting, NCI Thesaurus)

These leukemias may have normal karyotypes or additional chromosomal aberrations.

(Acute Myeloid Leukemia with Gene Mutations, NCI Thesaurus)

A chromosomal aberration involving the gene and the CREBBP gene, translocation t(10;16)(q22;p13), is associated with acute myeloid leukemias.

(KAT6B wt Allele, NCI Thesaurus)

These can be created by chromosomal aberration or by laboratory methods.

(Fusion gene, NCI Thesaurus)

Acute myeloid leukemia can be associated with chromosomal aberrations of the gene.

(KAT6A wt Allele, NCI Thesaurus)

A chromosomal aberration involving this gene, translocation t(7;17)(p15;q21) with the SUZ12 gene, is associated with endometrial stromal tumors.

(JAZF1 wt Allele, NCI Thesaurus)

An alkylating antineoplastic agent no longer used in the United States, because it induces chromosomal aberration and causes cancer.

(Chlornaphazine, NCI Thesaurus)

A chromosomal aberration t(15;19)(q13;p13.1) involving the gene and the human C15orf55 gene is associated with a lethal midline thoracic, head and neck carcinoma.

(BRD4 wt Allele, NCI Thesaurus)

A chromosomal aberration involving this gene and the MLL gene, insertion ins(5;11)(q31;q13q23), is associated with acute lymphoblastic leukemia.

(AFF4 wt Allele, NCI Thesaurus)