CHLORAMBUCIL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does chlorambucil mean? 

• CHLORAMBUCIL (noun)
  The noun CHLORAMBUCIL has 1 sense:

1. an alkylating agent (trade name Leukeran) used to treat some kinds of cancer

  Familiarity information: CHLORAMBUCIL used as a noun is very rare.

 Dictionary entry details 

• CHLORAMBUCIL (noun)

Sense 1

Meaning:

An alkylating agent (trade name Leukeran) used to treat some kinds of cancer

Classified under:

Nouns denoting man-made objects

Synonyms:

chlorambucil; Leukeran

Hypernyms ("chlorambucil" is a kind of...):

alkylating agent (an antineoplastic drug used to treat some forms of cancer)

 Context examples 

The drugs mechlorethamine and vincristine from the MOPP regimen have been replaced with chlorambucil and vinblastine to minimize gonadal and neurological toxicity, respectively.

(chlVPP Regimen, NCI Thesaurus)

A regimen derived from the original MOPP-ABVD regimen, consisting of etoposide, vinblastine, doxorubicin (EVA) and chlorambucil, vincristine, procarbazine, prednisone (ABVD), used for the initial treatment of Hodgkin's lymphoma.

(EVA-ChlVPP Regimen, NCI Thesaurus)

A regimen consisting of methotrexate, dactinomycin (Actinomycin-D) and chlorambucil, used for the treatment of good-prognosis metastatic gestational trophoblastic tumors (GTT).

(MAC Regimen, NCI Thesaurus)

A chemotherapy regimen consisting of chlorambucil and prednisone used for the treatment of chronic lymphocytic leukemia.

(Chlorambucil-prednisone regimen, NCI Thesaurus)

A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)

Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

(Chlorambucil, NCI Thesaurus)

It includes the drugs chlorambucil hydrochloride and prednisone.

(Chlorambucil-prednisone, NCI Dictionary)

The benzoate of a estradiol-chlorambucil conjugate.

(Atrimustine, NCI Thesaurus)

Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication.

(Mechlorethamine, NCI Thesaurus)

Also called chlorambucil.

(Leukeran, NCI Dictionary)