CHELATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does chelation mean? 

• CHELATION (noun)
  The noun CHELATION has 2 senses:

1. (medicine) the process of removing a heavy metal from the bloodstream by means of a chelate as in treating lead or mercury poisoning

2. the process of forming a ring by forming one or more hydrogen bonds

  Familiarity information: CHELATION used as a noun is rare.

 Dictionary entry details 

• CHELATION (noun)

Sense 1

Meaning:

(medicine) the process of removing a heavy metal from the bloodstream by means of a chelate as in treating lead or mercury poisoning

Classified under:

Nouns denoting natural processes

Hypernyms ("chelation" is a kind of...):

physical process; process (a sustained phenomenon or one marked by gradual changes through a series of states)

Domain category:

medical specialty; medicine (the branches of medical science that deal with nonsurgical techniques)

Derivation:

chelate (form a chelate, in chemistry)

Sense 2

Meaning:

The process of forming a ring by forming one or more hydrogen bonds

Classified under:

Nouns denoting natural processes

Hypernyms ("chelation" is a kind of...):

chemical action; chemical change; chemical process ((chemistry) any process determined by the atomic and molecular composition and structure of the substances involved)

Derivation:

chelate (form a chelate, in chemistry)

 Context examples 

This gene is involved in chelation.

(MT1G Gene, NCI Thesaurus)

It has calcium chelation activity but seems to inhibit growth of sensitive cells by disrupting nucleoside uptake and metabolism.

(Carbetimer, NCI Thesaurus)

An example is treating heart disease with chelation therapy (which seeks to remove excess metals from the blood) instead of using a standard approach.

(Complementary and Alternative Medicine, NIH: National Center for Complementary and Alternative Medicine)

Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.

(Clioquinol, NCI Thesaurus)

An immunoconjugate of the monoclonal antibody ibritumomab conjugated with the linker-chelator tiuxetan, a high affinity, conformationally restricted chelation site for radioisotopes.

(Ibritumomab tiuxetan, NCI Thesaurus)

This agent also causes inhibition of phosphorylation of myosin protein or chelation of trace metals required for smooth muscle contraction, thereby resulting in an increase in heart rate, stroke volume and cardiac output.

(Hydralazine, NCI Thesaurus)

This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output.

(Hydralazine Hydrochloride, NCI Thesaurus)