CHARCOT-MARIE-TOOTH DISEASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does Charcot-Marie-Tooth disease mean? 

• CHARCOT-MARIE-TOOTH DISEASE (noun)
  The noun CHARCOT-MARIE-TOOTH DISEASE has 1 sense:

1. a form of neuropathy that can begin between childhood and young adulthood; characterized by weakness and atrophy of the muscles of the hands and lower legs; progression is slow and individuals affected can have a normal life span; inheritance is X-linked recessive or X-linked dominant

  Familiarity information: CHARCOT-MARIE-TOOTH DISEASE used as a noun is very rare.

 Dictionary entry details 

• CHARCOT-MARIE-TOOTH DISEASE (noun)

Sense 1

Meaning:

A form of neuropathy that can begin between childhood and young adulthood; characterized by weakness and atrophy of the muscles of the hands and lower legs; progression is slow and individuals affected can have a normal life span; inheritance is X-linked recessive or X-linked dominant

Classified under:

Nouns denoting stable states of affairs

Synonyms:

Charcot-Marie-Tooth disease; hereditary motor and sensory neuropathy

Hypernyms ("Charcot-Marie-Tooth disease" is a kind of...):

neuropathy (any pathology of the peripheral nerves)

 Context examples 

Mutation of the gene is associated with Charcot-Marie-Tooth disease types 2A2 and 6.

(MFN2 wt Allele, NCI Thesaurus)

Certain allelic variants of the NDRG1 gene cause Charcot-Marie-Tooth disease type 4D.

(NDRG1 wt Allele, NCI Thesaurus)

Mutation of the gene is associated with Charcot-Marie-Tooth disease types 1F and 2E.

(NEFL wt Allele, NCI Thesaurus)

Mutation of the gene is associated with both distal hereditary motor neuronopathy type 2A and Charcot-Marie-Tooth disease type 2L.

(HSPB8 wt Allele, NCI Thesaurus)

Mutations in this gene are associated with Charcot-Marie-Tooth disease type 4H (CMT4H).

(FGD4 wt Allele, NCI Thesaurus)

Charcot-Marie-Tooth disease caused by mutations in the PMP22 gene (mapped to chromosome 17), resulting in peripheral nerve demyelination.

(Charcot-Marie-Tooth Disease Type 1A, NCI Thesaurus)

Mutation of the gene is associated with centronuclear myopathy type 1 and Charcot-Marie-Tooth disease types dominant intermediate B and 2M axonal.

(DNM2 wt Allele, NCI Thesaurus)

Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders.

(Charcot-Marie-Tooth Disease, NIH: National Institute of Neurological Disorders and Stroke)