CFTR

Pronunciation (US):

(GB):

 Dictionary entry overview: What does CFTR mean? 

• CFTR (noun)
  The noun CFTR has 1 sense:

1. the gene that is mutated in cystic fibrosis

  Familiarity information: CFTR used as a noun is very rare.

 Dictionary entry details 

• CFTR (noun)

Sense 1

Meaning:

The gene that is mutated in cystic fibrosis

Classified under:

Nouns denoting body parts

Synonyms:

CFTR; cystic fibrosis transport regulator

Hypernyms ("CFTR" is a kind of...):

mutant gene (a gene that has changed so that the normal transmission and expression of a trait is affected)

 Context examples 

Mutations in a single gene, called the Cystic Fibrosis Transmembrane Regulator (CFTR) gene, cause cystic fibrosis.

(Diagnosing cystic fibrosis with wearable devices, NIH)

The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific signaling of the channel.

(CFTR Pathway, NCI Thesaurus/BIOCARTA)

Cystic fibrosis transmembrane conductance regulator (1480 aa, ~168 kDa) is encoded by the human CFTR gene.

(Cystic Fibrosis Transmembrane Conductance Regulator, NCI Thesaurus)

Cystic fibrosis is caused by a defect in a gene called CFTR (cystic fibrosis transmembrane conductance regulator).

(Scientists find new approach that shows promise for treating cystic fibrosis, National Institutes of Health)

Human CFTR wild-type allele is located in the vicinity of 7q31.2 and is approximately 203 kb in length.

(CFTR wt Allele, NCI Thesaurus)

Mammalian P-glycoproteins are encoded by the MDR gene family and belong to the ATP-binding cassette vectorial transport protein class; the CFTR chloride channel is also a family member.

(Multidrug Resistance Gene, NCI Thesaurus)

This increases the concentration of intracellular cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). cGMP activates the cystic fibrosis transmembrane conductance regulator (CFTR) and stimulates the secretion of chloride and bicarbonate into the intestinal lumen.

(Linaclotide, NCI Thesaurus)

In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells.

(CFTR Pathway, NCI Thesaurus/BIOCARTA)

In normal cells, the CFTR protein acts as a channel that allows cells to release chloride and other ions.

(Diagnosing cystic fibrosis with wearable devices, NIH)

The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin.

(CFTR Pathway, NCI Thesaurus/BIOCARTA)