CELL DEATH

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 Dictionary entry overview: What does cell death mean? 

• CELL DEATH (noun)
  The noun CELL DEATH has 1 sense:

1. (physiology) the normal degeneration and death of living cells (as in various epithelial cells)

  Familiarity information: CELL DEATH used as a noun is very rare.

 Dictionary entry details 

• CELL DEATH (noun)

Sense 1

Meaning:

(physiology) the normal degeneration and death of living cells (as in various epithelial cells)

Classified under:

Nouns denoting natural phenomena

Synonyms:

cell death; necrobiosis

Hypernyms ("cell death" is a kind of...):

death (the permanent end of all life functions in an organism or part of an organism)

Domain category:

physiology (the branch of the biological sciences dealing with the functioning of organisms)

Hyponyms (each of the following is a kind of "cell death"):

apoptosis; caspase-mediated cell death; programmed cell death (a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival)

 Context examples 

This may induce cell death in tumor cells overexpressing this kinase.

(MET Tyrosine Kinase Inhibitor EMD 1204831, NCI Thesaurus)

Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors.

(Methazolamide, NCI Thesaurus)

Altogether, these IFN-g-mediated effects may result in an inhibition of tumor cell proliferation and tumor cell death.

(Adenovirus-Interferon-Gamma TG1042, NCI Thesaurus)

Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death.

(Nanoparticle Albumin-Bound Docetaxel, NCI Thesaurus)

Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells.

(mTOR1/2 Kinase Inhibitor ME-344, NCI Thesaurus)

Upon photoirradiation, PpIX is activated and transfers energy to oxygen, generating singlet oxygen and superoxide and hydroxyl radicals, which may result in free-radical-mediated DNA damage and cell death.

(Methyl-5-Aminolevulinate Hydrochloride Cream, NCI Thesaurus)

Methylene dimethane sulfonate alkylates DNA, resulting in interstrand DNA crosslinking, inhibition of DNA replication, disruption of the cell cycle, and cell death.

(Methylene Dimethane Sulfonate, NCI Thesaurus)

Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.

(Acridine carboxamide, NCI Thesaurus)

This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.

(Acridine, NCI Thesaurus)

Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death.

(Micafungin, NCI Thesaurus)