CD8

 Dictionary entry overview: What does CD8 mean? 

• CD8 (noun)
  The noun CD8 has 1 sense:

1. a membrane glycoprotein that is found primarily on the surface of cytotoxic T cells

  Familiarity information: CD8 used as a noun is very rare.

 Dictionary entry details 

• CD8 (noun)

Sense 1

Meaning:

A membrane glycoprotein that is found primarily on the surface of cytotoxic T cells

Classified under:

Nouns denoting substances

Synonyms:

CD8; cluster of differentiation 8

Hypernyms ("CD8" is a kind of...):

glycoprotein (a conjugated protein having a carbohydrate component)

 Context examples 

IL-21, a cytokine involved in the regulation of cellular immune responses, may play a key role during priming of antigen-specific CD8+ T cells and may enhance proliferation of the CTLs.

(Autologous IL-21-Modulated CD8+ MART1-Specific T Cells, NCI Thesaurus)

The autologous lymphoid effector cells are prepared by drawing a blood sample containing the required precursors for CD4+ helper T-cells, CD8+ cytotoxic T-cells, and natural killer (NK) cells from a cancer patient.

(Autologous Lymphoid Effector Cells Specific Against Tumor Cells, NCI Thesaurus)

A preparation of autologous CD8+ (cytotoxic) T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities.

(Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes, NCI Thesaurus)

Vaccination with these altered cells may elicit an anti-tumor immune response via CD8+ cytotoxic T lymphocytes (CTL).

(B7 Transfected Melanoma Cell Vaccine, NCI Thesaurus)

PD-1, a transmembrane protein expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells.

(Anti-PD-L1 Monoclonal Antibody MPDL3280A, NCI Thesaurus)

After expansion in culture and reintroduction into the patient, the anti-VEGFR2 CAR-gene engineered CD8+ lymphocytes express anti-VEGFR2-CAR on their cell surfaces and bind to the VEGFR2 antigen on tumor cell surfaces.

(Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes, NCI Thesaurus)

A preparation of autologous CD8+ (cytotoxic) human peripheral blood lymphocytes (PBLs) sensitized to Drosophila cell-presented melanoma peptides, with potential immunostimulating and antineoplastic activities.

(Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides, NCI Thesaurus)

A lymphopenic, nondiabetic substrain BB-DR has very low T-cell numbers, depressed B-lymphocyte numbers and a complete absence of peripheral CD8+ T cells characteristics of the susceptible BB strain(Joseph et al 1993).

(BB, Rat Strain, NCI Thesaurus)

Present peptides to CD8+ T cells.

(MHC Class I Gene, NCI Thesaurus)

Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR) to suppress antibody production by B-cells.

(Murine T-Lymphocytes, Suppressor-Inducer, NLM, Medical Subject Headings)