CD4

 Dictionary entry overview: What does CD4 mean? 

• CD4 (noun)
  The noun CD4 has 1 sense:

1. a glycoprotein that is found primarily on the surface of helper T cells

  Familiarity information: CD4 used as a noun is very rare.

 Dictionary entry details 

• CD4 (noun)

Sense 1

Meaning:

A glycoprotein that is found primarily on the surface of helper T cells

Classified under:

Nouns denoting substances

Synonyms:

CD4; cluster of differentiation 4

Context example:

CD4 is a receptor for HIV in humans

Hypernyms ("CD4" is a kind of...):

glycoprotein (a conjugated protein having a carbohydrate component)

 Context examples 

This allele, which encodes T-cell-specific surface glycoprotein CD28 protein, is involved in the costimulation that is essential for CD4 -positive T-cell proliferation, survival, interleukin-2 production, and T-helper type-2 (Th2) development.

(CD28 wt Allele, NCI Thesaurus)

This allele, which encodes small inducible cytokine A18 protein, is involved in the chemotactic regulation of naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes.

(CCL18 wt Allele, NCI Thesaurus)

CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells.

(CD3 Complex, NCI Thesaurus)

CD4 Antigen, encoded by the CD4 gene, is a T-cell surface glycoprotein.

(CD4 Antigen, NCI Thesaurus)

This elicits a targeted CD4+ and CD8+ T-lymphocyte-mediated immune response.

(Brachyury-expressing Yeast Vaccine GI-6301, NCI Thesaurus)

This may enhance recognition of tumors by the immune system, and activate both cytotoxic CD8+ T cells and CD4+ helper T cells against tumor cells.

(Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine, NCI Thesaurus)

OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed by CD4 T cells and provides a costimulatory signal for T cell activation.

(Anti-OX40 Monoclonal Antibody, NCI Thesaurus)

White blood cells called CD4 T cells can mature to become many types of T cells, each of which has a distinct function.

(Autoimmune Disease Super-Regulators Uncovered, NIH)

Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma.

(Autologous Ad-CD154-Transduced CLL B Cells, NCI Thesaurus)

The autologous lymphoid effector cells are prepared by drawing a blood sample containing the required precursors for CD4+ helper T-cells, CD8+ cytotoxic T-cells, and natural killer (NK) cells from a cancer patient.

(Autologous Lymphoid Effector Cells Specific Against Tumor Cells, NCI Thesaurus)