CASPASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does caspase mean? 

• CASPASE (noun)
  The noun CASPASE has 1 sense:

1. any of a group of proteases that mediate apoptosis

  Familiarity information: CASPASE used as a noun is very rare.

 Dictionary entry details 

• CASPASE (noun)

Sense 1

Meaning:

Any of a group of proteases that mediate apoptosis

Classified under:

Nouns denoting substances

Hypernyms ("caspase" is a kind of...):

peptidase; protease; proteinase; proteolytic enzyme (any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis)

 Context examples 

Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.

(Apoptosis Pathway, NCI Thesaurus/KEGG)

This protein plays a role in promotion of caspase activation and the initiation of apoptosis.

(Apoptosis-Associated Speck-Like Protein Containing A CARD, NCI Thesaurus)

Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria.

(Apoptotic DNA Fragmentation Pathway, NCI Thesaurus/BIOCARTA)

Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway.

(Mitochondria in Apoptotic Signaling Pathway, NCI Thesaurus/BIOCARTA)

This protein is involved in the activation of caspases and the immune response to bacterial challenge.

(Nucleotide-Binding Oligomerization Domain-Containing Protein 2, NCI Thesaurus)

This protein is released from the full length chromogranin-A protein by caspase cleavage and plays a role in the inhibition of the release of chromogranin-A, parathyroid hormone and somatostatin.

(Pancreastatin, NCI Thesaurus)

This agent may also exhibit anti-angiogenic activity, possibly by inducing endothelial cell apoptosis via modulation of the transcription factor NF-kB, the Bcl-2 family of proteins, and caspases.

(Phosphatidylcholine-Bound Silybin, NCI Thesaurus)

On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes.

(NOD-Like Receptor Signaling Pathway, NCI Thesaurus/KEGG)

Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation.

(mTOR1/2 Kinase Inhibitor ME-344, NCI Thesaurus)

This protein is involved in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.

(Mitogen-Activated Protein Kinase Kinase Kinase 5, NCI Thesaurus)