BREAKAGE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does breakage mean? 

• BREAKAGE (noun)
  The noun BREAKAGE has 3 senses:

1. the quantity broken

2. reimbursement for goods damaged while in transit or in use

3. the act of breaking something

  Familiarity information: BREAKAGE used as a noun is uncommon.

 Dictionary entry details 

• BREAKAGE (noun)

Sense 1

Meaning:

The quantity broken

Classified under:

Nouns denoting quantities and units of measure

Context example:

the total breakage was huge

Hypernyms ("breakage" is a kind of...):

indefinite quantity (an estimated quantity)

Sense 2

Meaning:

Reimbursement for goods damaged while in transit or in use

Classified under:

Nouns denoting possession and transfer of possession

Hypernyms ("breakage" is a kind of...):

reimbursement (compensation paid (to someone) for damages or losses or money already spent etc.)

Sense 3

Meaning:

The act of breaking something

Classified under:

Nouns denoting acts or actions

Synonyms:

break; breakage; breaking

Context example:

the breakage was unavoidable

Hypernyms ("breakage" is a kind of...):

change of integrity (the act of changing the unity or wholeness of something)

Hyponyms (each of the following is a kind of "breakage"):

rupture (the act of making a sudden noisy break)

shattering; smashing (the act of breaking something into small pieces)

crack; cracking; fracture (the act of cracking something)

chip; chipping; splintering (the act of chipping something)

Derivation:

break (render inoperable or ineffective)

break (destroy the integrity of; usually by force; cause to separate into pieces or fragments)

break (break a piece from a whole)

break (ruin completely)

 Context examples 

Fusion proteins can be formed by chromosomal breakage and/or recombination and also can be experimentally created using recombinant DNA techniques.

(Fusion protein, NCI Thesaurus)

Nijmegen breakage syndrome is also a disease characterized by chromosomal and genomic instability.

(Genomic Instability, NCI Thesaurus)

As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.

(Elliptinium, NCI Thesaurus)

Intercalation inhibits topoisomerase II activity and causing DNA stand breakage, thereby leads to inhibition of DNA, RNA, and protein synthesis.

(Elinafide, NCI Thesaurus)

TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands.

(DNA Topoisomerase II Binding Protein, NCI Thesaurus/LocusLink)

This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction.

(Homologous Recombination, NCI Thesaurus)

This ultimately results in an inhibition of DNA replication, inducing double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering apoptosis.

(Lurtotecan Liposome, NCI Thesaurus)

NBS1 mutations are associated with Nijmegen breakage syndrome, chromosomal instability, cancer, and cell cycle checkpoint defects.

(Nibrin, NCI Thesaurus)

As a result, this agent causes DNA adducts formation, renders single- and double-stranded DNA breakages that induce DNA repair and or apoptotic processes.

(Pegylated Liposomal Doxorubicin Hydrochloride, NCI Thesaurus)

Functional mutations in the NBN gene produce allelic variants that are involved in Nijmegen breakage syndrome.

(NBN wt Allele, NCI Thesaurus)