BIVALENT

Pronunciation (US):

(GB):

 Dictionary entry overview: What does bivalent mean? 

• BIVALENT (adjective)
  The adjective BIVALENT has 2 senses:

1. having a valence of two or having two valences

2. used of homologous chromosomes associated in pairs in synapsis

  Familiarity information: BIVALENT used as an adjective is rare.

 Dictionary entry details 

• BIVALENT (adjective)

Sense 1

Meaning:

Having a valence of two or having two valences

Classified under:

Relational adjectives (pertainyms)

Synonyms:

bivalent; divalent

Domain category:

chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)

Pertainym:

valence ((chemistry) a property of atoms or radicals; their combining power given in terms of the number of hydrogen atoms (or the equivalent))

Sense 2

Meaning:

Used of homologous chromosomes associated in pairs in synapsis

Synonyms:

bivalent; double

Attribute:

valence; valency ((biology) a relative capacity to unite or react or interact as with antigens or a biological substrate)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Antonym:

multivalent (used of the association of three or more homologous chromosomes during the first division of meiosis)

univalent (used of a chromosome that is not paired or united with its homologous chromosome during synapsis)

 Context examples 

A bivalent recombinant fusion protein immunotoxin derived from the anti-CD3 monoclonal antibody UCHT1 with potential antineoplastic activity.

(Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1), NCI Thesaurus)

It is a type of bivalent vaccine (a vaccine that works against two different viruses or other microorganisms).

(Cervarix, NCI Dictionary)

Vaccination with GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine may elicit antibodies against tumor cells expressing either epitope, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC).

(GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent Vaccine, NCI Thesaurus)

A recombinant, bivalent, human papillomavirus (HPV) vaccine, containing virus-like particles for HPV types 16 and 18 linked to the adjuvant ASO4, with potential immunoprotective and antineoplastic properties.

(Human Papillomavirus 16/18 L1 Virus-Like Particle/AS04 Vaccine, NCI Thesaurus)

It is a type of bivalent vaccine.

(Human Papillomavirus 16/18 L1 Virus-Like Particle/AS04 Vaccine, NCI Dictionary)

A crystalline, white substance, soluble in water, Calcium Chloride is the chloride salt of calcium, a bivalent metallic element with many crucial biological roles.

(Calcium Chloride, NCI Thesaurus)

DTPA (diethylenetriaminepentaacetic acid) is a bivalent hapten.

(Anti-CEA/Anti-DTPA-In (F6-734) Bispecific Antibody, NCI Thesaurus)

A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity.

(Bispecific Antibody MDX-H210, NCI Thesaurus)

For example, Cervarix is a bivalent vaccine that helps protect the body against infection with human papillomaviruses (HPV) types 16 and 18.

(Bivalent vaccine, NCI Dictionary)

The SWI/SNF remodeling machine arrives at the promoter via bivalent interactions with CBP and the acetylated histone N tails.

(IFN-Beta Enhancer Pathway, NCI Thesaurus/BIOCARTA)