APICAL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does apical mean? 

• APICAL (adjective)
  The adjective APICAL has 1 sense:

1. situated at an apex

  Familiarity information: APICAL used as an adjective is very rare.

 Dictionary entry details 

• APICAL (adjective)

Sense 1

Meaning:

Situated at an apex

Similar:

top (situated at the top or highest position)

Derivation:

apex (the point on the celestial sphere toward which the sun and solar system appear to be moving relative to the fixed stars)

apex (the highest point (of something))

 Context examples 

The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase.

(Intercalated Cell, NCI Thesaurus)

The SLC22A1L organic cation transporter protein is localized on the apical surface of renal proximal tubules and appears to confer resistance/transport activity to chloroquine and quinidine-related compounds.

(Organic Cation Transporter-Like 2 Protein, NCI Thesaurus)

The finger-like projections that increase the surface area of the apical membrane of the thin layer of tissue that covers organs, glands, and other structures within the body.

(Epithelial Microvillus, NCI Thesaurus)

This protein may play a role in apical domain protein localization and function.

(PDZK1-Interacting Protein 1, NCI Thesaurus)

Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium.

(Lubiprostone, NCI Thesaurus)

A malignant neoplasm originating from the apical lung.

(Malignant Superior Sulcus Neoplasm, NCI Thesaurus)

MDR1 and MDR2 P-glycoproteins are large apical cell membrane proteins overproduced in multidrug-resistant (MDR) cancer cells resistant to diverse hydrophobic drugs.

(Multidrug Resistance Gene, NCI Thesaurus)

They send to the surface of the epithelium apical dendrites with non-motile cilia from which project odorant receptor molecules.

(Murine Olfactory Receptor Neurons, NLM, Medical Subject Headings)

A cement like material used for apical seals and as a reparative material for perforation of the tooth root.

(MTA Cement, NCI Thesaurus)

Mitoses are rare, but when present are non-luminal (not apical) and not atypical.

(Mouse Pancreatic Intraepithelial Neoplasia-2, NCI Thesaurus/MMHCC)