ANTIMETABOLITE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does antimetabolite mean? 

• ANTIMETABOLITE (noun)
  The noun ANTIMETABOLITE has 1 sense:

1. an antineoplastic drug that inhibits the utilization of a metabolite

  Familiarity information: ANTIMETABOLITE used as a noun is very rare.

 Dictionary entry details 

• ANTIMETABOLITE (noun)

Sense 1

Meaning:

An antineoplastic drug that inhibits the utilization of a metabolite

Classified under:

Nouns denoting man-made objects

Hypernyms ("antimetabolite" is a kind of...):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

Hyponyms (each of the following is a kind of "antimetabolite"):

fluorouracil (an antimetabolite used to treat certain cancers)

mercaptopurine; Purinethol (a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia)

amethopterin; methotrexate; methotrexate sodium (toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis)

 Context examples 

An anticancer drug that is a type of antimetabolite.

(Fazarabine, NCI Dictionary)

As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.

(Floxuridine, NCI Thesaurus)

A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity.

(Fludarabine, NCI Thesaurus)

A pyrimidine antimetabolite converted to Cytarabine in the body.

(Enocitabine, NCI Thesaurus)

Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity.

(Eniluracil / 5-FU Combination Tablet, NCI Thesaurus)

An anticancer drug that belongs to a family of drugs called antimetabolites.

(Edatrexate, NCI Dictionary)

An orally available antimetabolite composed of the 1-ethoxymethyl derivative of 5-fluorouracil (5-FU) and the dihydropyrimidine dehydrogenase (DPYD) inhibitor 3-cyano-2,6-dihydroxypyridine (CNDP) in a 1:1 molar ratio, with antineoplastic activity.

(Emitefur, NCI Thesaurus)

The sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity.

(Emofolin Sodium, NCI Thesaurus)

The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity.

(Fludarabine phosphate, NCI Thesaurus)

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities.

(Mercaptopurine, NCI Thesaurus)