ANTAGONISTIC

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does antagonistic mean? 

• ANTAGONISTIC (adjective)
  The adjective ANTAGONISTIC has 5 senses:

1. indicating opposition or resistance

2. characterized by antagonism or antipathy

3. arousing animosity or hostility

4. used especially of drugs or muscles that counteract or neutralize each other's effect

5. incapable of harmonious association

  Familiarity information: ANTAGONISTIC used as an adjective is common.

 Dictionary entry details 

• ANTAGONISTIC (adjective)

Sense 1

Meaning:

Indicating opposition or resistance

Synonyms:

antagonistic; counter

Similar:

negative (characterized by or displaying negation or denial or opposition or resistance; having no positive features)

Derivation:

antagonism (the relation between opposing principles or forces or factors)

antagonist (someone who offers opposition)

Sense 2

Meaning:

Characterized by antagonism or antipathy

Synonyms:

antagonistic; antipathetic; antipathetical

Context example:

antipathetic factions within the party

Similar:

hostile (characterized by enmity or ill will)

Derivation:

antagonism (the relation between opposing principles or forces or factors)

antagonism (a state of deep-seated ill-will)

Sense 3

Meaning:

Arousing animosity or hostility

Context example:

Europe was antagonistic to the Unites States

Similar:

alienating (causing hostility or loss of friendliness)

Antonym:

conciliatory (intended to placate)

Derivation:

antagonism (an actively expressed feeling of dislike and hostility)

Sense 4

Meaning:

Used especially of drugs or muscles that counteract or neutralize each other's effect

Synonyms:

antagonistic; incompatible

Similar:

antacid (acting to neutralize acid (especially in the stomach))

antiphlogistic (counteracting inflammation)

Antonym:

synergistic (used especially of drugs or muscles that work together so the total effect is greater than the sum of the two (or more))

Derivation:

antagonism ((biochemistry) interference in or inhibition of the physiological action of a chemical substance by another having a similar structure)

antagonist (a drug that neutralizes or counteracts the effects of another drug)

antagonist (a muscle that relaxes while another contracts)

Sense 5

Meaning:

Incapable of harmonious association

Similar:

incompatible (not compatible)

Derivation:

antagonism (a state of deep-seated ill-will)

 Context examples 

The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties.

(Meclizine Hydrochloride, NCI Thesaurus)

A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity.

(Methylnaltrexone, NCI Thesaurus)

The bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic activity.

(Methylnaltrexone bromide, NCI Thesaurus)

This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.

(Lansoprazole, NCI Thesaurus)

The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.

(Haloperidol Decanoate, NCI Thesaurus)

The acetate salt form of ganirelix, a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH).

(Ganirelix Acetate, NCI Thesaurus)

Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity.

(Haloperidol, NCI Thesaurus)

The hydrochloride salt form of nalmefene, a naltrexone analogue with opioid antagonistic property.

(Nalmefene Hydrochloride, NCI Thesaurus)

A thebaine derivate with competitive opioid antagonistic properties.

(Naloxone, NCI Thesaurus)

GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins.

(Pan-Selectin Antagonist GMI-1070, NCI Thesaurus)