AMYOTROPHIC LATERAL SCLEROSIS

Pronunciation (US):

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IPA (US):

 Dictionary entry overview: What does amyotrophic lateral sclerosis mean? 

• AMYOTROPHIC LATERAL SCLEROSIS (noun)
  The noun AMYOTROPHIC LATERAL SCLEROSIS has 1 sense:

1. thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord; results in progressive muscle atrophy that starts in the limbs

  Familiarity information: AMYOTROPHIC LATERAL SCLEROSIS used as a noun is very rare.

 Dictionary entry details 

• AMYOTROPHIC LATERAL SCLEROSIS (noun)

Sense 1

Meaning:

Thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord; results in progressive muscle atrophy that starts in the limbs

Classified under:

Nouns denoting stable states of affairs

Synonyms:

ALS; amyotrophic lateral sclerosis; Lou Gehrig's disease

Hypernyms ("amyotrophic lateral sclerosis" is a kind of...):

nervous disorder; neurological disease; neurological disorder (a disorder of the nervous system)

induration; sclerosis (any pathological hardening or thickening of tissue)

 Context examples 

Mutation of the gene is associated with angiomatoid fibrous histiocytoma and amyotrophic lateral sclerosis.

(FUS wt Allele, NCI Thesaurus)

They include those with disabilities, permanent kidney failure, or amyotrophic lateral sclerosis.

(Medicare, NIH)

Mutations in the gene are associated with greater susceptibility to amyotrophic lateral sclerosis.

(NEFH wt Allele, NCI Thesaurus)

Other causes of paralysis include: • Nerve diseases such as amyotrophic lateral sclerosis • Autoimmune diseases such as Guillain-Barre syndrome • Bell's palsy, which affects muscles in the face

(Paralysis, NIH)

An expanded GGGGCC hexanucleotide repeat in the non-coding region of the C9orf72 gene is associated with amyotrophic lateral sclerosis and frontotemporal dementia.

(C9orf72 wt Allele, NCI Thesaurus)

Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria.

(Amyotrophic Lateral Sclerosis Pathway, NCI Thesaurus/KEGG)

Interestingly, ATXN2 is the third gene found to be associated with both glaucoma and amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

(Glaucoma-related genes revealed, NIH)

Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) is the most common type of motor neuron disease.

(Motor neuron disease, NCI Dictionary)

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord.

(Amyotrophic Lateral Sclerosis, NIH: National Institute of Neurological Disorders and Stroke)

Defects in cellular trafficking have been linked to other neurological disorders, such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and Alzheimer’s disease, suggesting that certain nerve cell pathways are particularly sensitive to impairment of this process.

(Study in mice identifies type of brain cell involved in stuttering, National Institutes of Health)