ADA

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 Dictionary entry overview: What does ADA mean? 

• ADA (noun)
  The noun ADA has 1 sense:

1. an enzyme found in mammals that can catalyze the deamination of adenosine into inosine and ammonia

  Familiarity information: ADA used as a noun is very rare.

 Dictionary entry details 

• ADA (noun)

Sense 1

Meaning:

An enzyme found in mammals that can catalyze the deamination of adenosine into inosine and ammonia

Classified under:

Nouns denoting substances

Synonyms:

ADA; adenosine deaminase

Context example:

the gene encoding ADA was one of the earlier human genes to be isolated and cloned for study

Hypernyms ("ADA" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

 Context examples 

Autologous hematopoietic CD34+ cells are isolated from the patient’s own bone marrow, peripheral blood or cord blood, and transduced with the EFS-ADA lentiviral vector ex vivo.

(EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes, NCI Thesaurus)

Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase.

(Pentostatin, NCI Thesaurus)

T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA.

(ADA Transduced T Cell, NCI Thesaurus)

Adenosine deaminase (363 aa, ~41 kDa) is encoded by the human ADA gene.

(Adenosine Deaminase, NCI Thesaurus)

Human ADA wild-type allele is located within 20q12-q13.11 and is approximately 32 kb in length.

(ADA wt Allele, NCI Thesaurus)

Upon re-infusion of the EFS-ADA vector-transduced lymphocytes back into the patient, these cells may both restore ADA activity and prevent severe combined immunodeficiency (SCID) due to ADA deficiency.

(EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes, NCI Thesaurus)

ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID).

(ADA Transduced T Cell, NCI Thesaurus)

Certain allelic variants of the ADA gene are associated with adenosine deaminase deficiency which, in some cases, causes autosomal recessive severe combined immunodeficiency.

(ADA wt Allele, NCI Thesaurus)

Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies.

(Pentostatin, NCI Thesaurus)

ADA, an enzyme that catalyzes the deamination of adenosine to inosine, plays a key role in the development and functioning of the immune system.

(EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes, NCI Thesaurus)