ACTIVATOR

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does activator mean? 

• ACTIVATOR (noun)
  The noun ACTIVATOR has 1 sense:

1. (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription

  Familiarity information: ACTIVATOR used as a noun is very rare.

 Dictionary entry details 

• ACTIVATOR (noun)

Sense 1

Meaning:

(biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription

Classified under:

Nouns denoting substances

Hypernyms ("activator" is a kind of...):

substance (the real physical matter of which a person or thing consists)

Domain category:

biological science; biology (the science that studies living organisms)

Hyponyms (each of the following is a kind of "activator"):

activating agent ((mineral extraction) a surface-active chemical used in flotation process to increase the attraction to a specific mineral)

accelerator; catalyst ((chemistry) a substance that initiates or accelerates a chemical reaction without itself being affected)

sensitiser; sensitizer ((chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction)

Antonym:

inhibitor (a substance that retards or stops an activity)

Derivation:

activate (make active or more active)

 Context examples 

The p53 protein is employed as a transcriptional activator of p53-regulated genes.

(p53 Signaling Pathway KEGG, NCI Thesaurus/KEGG)

Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation.

(Oncogene MYB, NCI Thesaurus)

Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands.

(Pancreatic Cancer Pathway, NCI Thesaurus/KEGG)

It is a transcriptional activator and major regulator of viral DNA replication and gene expression.

(Papillomavirus Protein E2, NCI Thesaurus)

An antisense oligonucleotide targeting mRNA of the chimeric PAX3/FKHR fusion gene, an oncogenic transcriptional activator found in rhabdomyosarcomas.

(PAX3/FKHR, NCI Thesaurus)

Activation may be provided by contact with the glass tube or exposure to activators (e.g., ellagic acid, particulate silicates such as diatomaceous earth or kaolin) before addition of the calcium chloride.

(Partial Thromboplastin Time, NLM, Medical Subject Headings)

E1A interacts with general and specific transcription factors, co-activators and chromatin-modifying enzymes.

(Oncogene E1A, NCI Thesaurus)

A member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity.

(Nrf2 Activator RTA 408, NCI Thesaurus)

Upon intravenous infusion, multikinase inhibitor SAR103168 may, through the inhibition of multiple kinases, inhibit the phosphorylation and activation of signal transducer and activator of transcription 5 (STAT5).

(Multikinase Inhibitor SAR103168, NCI Thesaurus)

Furthermore, this agent also inhibits tumor cell migration and invasion by inhibiting matrix metalloproteinase-9 (MMP-9) expression which is mediated through the suppression of transcription activator protein-1 (AP-1) activation.

(Metformin hydrochloride, NCI Thesaurus)