ACTINOMYCIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does actinomycin mean? 

• ACTINOMYCIN (noun)
  The noun ACTINOMYCIN has 1 sense:

1. any of various red antibiotics isolated from soil bacteria

  Familiarity information: ACTINOMYCIN used as a noun is very rare.

 Dictionary entry details 

• ACTINOMYCIN (noun)

Sense 1

Meaning:

Any of various red antibiotics isolated from soil bacteria

Classified under:

Nouns denoting man-made objects

Hypernyms ("actinomycin" is a kind of...):

antibiotic; antibiotic drug (a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections)

 Context examples 

Actinomycin F1 intercalates into the minor groove of DNA and binds to topoisomerase II, leading to the inhibition of DNA replication and RNA and protein synthesis.

(Actinomycin F1, NCI Thesaurus)

Also called actinomycin D and dactinomycin.

(Cosmegen, NCI Dictionary)

Also called actinomycin D and Cosmegen.

(Dactinomycin, NCI Dictionary)

Actinomycin D comes from the bacterium Streptomyces parvulus.

(actinomycin D, NCI Dictionary)

Actinomycin C3 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.

(Actinomycin C3, NCI Thesaurus)

A natural analogue of actinomycin, a chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces.

(Actinomycin C2, NCI Thesaurus)

Actinomycin antibiotics inhibit DNA replication and RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.

(Actinomycin Antineoplastic Antibiotic, NCI Thesaurus)

HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

(HL-60/MX1, NCI Thesaurus)

Actinomycin C2 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms including, intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.

(Actinomycin C2, NCI Thesaurus)

In addition, actinomycin C2 appears to block the interaction between the SH2 domain of growth factor receptor-bound protein-2 (GRB2) and the Src homology 2 domain containing transforming protein 1 adaptor protein SHC, which plays a key role in the Ras signaling pathway thereby halting cellular differentiation and proliferation.

(Actinomycin C2, NCI Thesaurus)