ACETYLATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does acetylate mean? 

• ACETYLATE (verb)
  The verb ACETYLATE has 2 senses:

1. receive substitution of an acetyl group

2. introduce an acetyl group into (a chemical compound)

  Familiarity information: ACETYLATE used as a verb is rare.

 Dictionary entry details 

• ACETYLATE (verb)

Present simple: I / you / we / they acetylate    ... he / she / it acetylates   
Past simple: acetylated   
Past participle: acetylated   
-ing form: acetylating   

Sense 1

Meaning:

Receive substitution of an acetyl group

Classified under:

Verbs of size, temperature change, intensifying, etc.

Synonyms:

acetylate; acetylise; acetylize

Context example:

the compounds acetylated

Hypernyms (to "acetylate" is one way to...):

change (undergo a change; become different in essence; losing one's or its original nature)

Domain category:

chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)

Sentence frame:

Something ----s

Derivation:

acetyl (the organic group of acetic acid (CH3CO-))

acetylation (the process of introducing an acetyl group into a compound)

Sense 2

Meaning:

Introduce an acetyl group into (a chemical compound)

Classified under:

Verbs of size, temperature change, intensifying, etc.

Synonyms:

acetylate; acetylise; acetylize

Hypernyms (to "acetylate" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Domain category:

chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)

Sentence frame:

Somebody ----s something

Derivation:

acetyl (the organic group of acetic acid (CH3CO-))

acetylation (the process of introducing an acetyl group into a compound)

 Context examples 

Histone deacetylation is probably a prerequisite for subsequent methylation, as histone tails cannot be acetylated and methylated in the same time.

(Gene Silencing Pathway, NCI Thesaurus/BIOCARTA)

The SWI/SNF remodeling machine arrives at the promoter via bivalent interactions with CBP and the acetylated histone N tails.

(IFN-Beta Enhancer Pathway, NCI Thesaurus/BIOCARTA)

Second, phosphorylated p53 dissociates from MDM2, is acetylated by p300/PCAF, binds DNA, and activates transcription of genes that inhibit Cdc2/cyclin (14-3-3s, GADD45, and p21Cip1).

(Negative Regulation of G2 to M Transition, NCI Thesaurus)

The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent.

(Daniquidone, NCI Thesaurus)

Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression.

(Givinostat, NCI Thesaurus)

HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.

(HDAC Inhibitor 4SC-202, NCI Thesaurus)

An N-acetylated, glycol-split form of heparin that is devoid of anticoagulant activity and is an inhibitor of heparanase with antineoplastic and antiangiogenic activities.

(Heparin Derivative SST0001, NCI Thesaurus)

CG200745 inhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression.

(HDAC inhibitor CG200745, NCI Thesaurus)

Bacterial chloramphenicol-O-acetyltransferase (cat) gene encodes chloramphenicol-O-acetyltransferase protein, an enzyme that acetylates the antiobiotic chloramphenicol to yield chloramphenicol 3-acetate.

(CAT Gene, NCI Thesaurus)

Bromodomain-containing proteins may recruit remodeling complexes to acetylated chromatin regions.

(Bromodomain, NCI Thesaurus)