ABROGATE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does abrogate mean? 

• ABROGATE (verb)
  The verb ABROGATE has 1 sense:

1. revoke formally

  Familiarity information: ABROGATE used as a verb is very rare.

 Dictionary entry details 

• ABROGATE (verb)

Present simple: I / you / we / they abrogate    ... he / she / it abrogates   
Past simple: abrogated   
Past participle: abrogated   
-ing form: abrogating   

Sense 1

Meaning:

Revoke formally

Classified under:

Verbs of political and social activities and events

Hypernyms (to "abrogate" is one way to...):

abolish; get rid of (do away with)

Sentence frame:

Somebody ----s something

Derivation:

abrogation (the act of abrogating; an official or legal cancellation)

abrogator (an authority or official empowered to abolish or annul or repeal)

 Context examples 

Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors.

(Leucine-Rich Glioma-Inactivated Protein, NCI Thesaurus)

Hypoxia or DNA damage by abrogating binding of HIF-1 with VHL and p53 with Mdm-2, respectively, leads to stabilization and accumulation of transcriptionally active HIF-1 and p53.

(Hypoxia Pathway, NCI Thesaurus/BIOCARTA)

Expression of the MGMT gene is abrogated via promoter hypermethylation in certain types of cancer such as brain neoplasms, gastric cancer, hepatocellular carcinoma and non-small cell lung cancer.

(MGMT wt Allele, NCI Thesaurus)

By preventing NO generation, the vasodilatory effects of NO are abrogated leading to vasoconstriction, reduction in vascular permeability and an inhibition of angiogenesis.

(NG-nitro-L-arginine, NCI Thesaurus)

This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.

(Phenprocoumon, NCI Thesaurus)

Administration of estradiol/norethindrone acetate may abrogate vasomotor symptoms associated with menopause and prevent bone loss associated with the postmenopause.

(Estradiol/Norethindrone Acetate Tablet, NCI Thesaurus)

Upon topical application of the EGF ointment, EGF locally activates EGFR, thereby abrogating EGFR inhibition in the skin caused by systemic EGFR inhibiting agents.

(Epidermal Growth Factor Ointment, NCI Thesaurus)

Upon administration, LY2606368 selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA.

(Checkpoint Kinase 1 Inhibitor LY2606368, NCI Thesaurus)

Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death.

(Custirsen sodium, NCI Thesaurus)

Darglitazone may be able to abrogate acute cerebral inflammatory responses via its suppression of proinflammatory gene expression.

(Darglitazone, NCI Thesaurus)