ABERRATION

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 Dictionary entry overview: What does aberration mean? 

• ABERRATION (noun)
  The noun ABERRATION has 3 senses:

1. a state or condition markedly different from the norm

2. a disorder in one's mental state

3. an optical phenomenon resulting from the failure of a lens or mirror to produce a good image

  Familiarity information: ABERRATION used as a noun is uncommon.

 Dictionary entry details 

• ABERRATION (noun)

Sense 1

Meaning:

A state or condition markedly different from the norm

Classified under:

Nouns denoting stable states of affairs

Synonyms:

aberrance; aberrancy; aberration; deviance

Hypernyms ("aberration" is a kind of...):

abnormalcy; abnormality (an abnormal physical condition resulting from defective genes or developmental deficiencies)

Hyponyms (each of the following is a kind of "aberration"):

chromosomal aberration; chromosomal anomaly; chromosonal disorder; chrosomal abnormality (any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities)

deflection; warp (a twist or aberration; especially a perverse or abnormal way of judging or acting)

Derivation:

aberrate (diverge or deviate from the straight path; produce aberration)

aberrate (diverge from the expected)

Sense 2

Meaning:

A disorder in one's mental state

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("aberration" is a kind of...):

disturbance; folie; mental disorder; mental disturbance; psychological disorder ((psychiatry) a psychological disorder of thought or emotion; a more neutral term than mental illness)

Derivation:

aberrate (diverge from the expected)

Sense 3

Meaning:

An optical phenomenon resulting from the failure of a lens or mirror to produce a good image

Classified under:

Nouns denoting natural phenomena

Synonyms:

aberration; distortion; optical aberration

Hypernyms ("aberration" is a kind of...):

optical phenomenon (a physical phenomenon related to or involving light)

Hyponyms (each of the following is a kind of "aberration"):

chromatic aberration (an optical aberration in which the image has colored fringes)

spherical aberration (an optical aberration resulting in a distorted image)

Derivation:

aberrate (diverge or deviate from the straight path; produce aberration)

 Context examples 

There is a recurrent cytogenetic aberration, most commonly t(11;22)(q24;q12) and t(21;22)(q22;q12).

(Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, NCI Thesaurus)

The most common aberration that has been identified is a t(11;22)(q24;q12) translocation.

(EWSR1 wt Allele, NCI Thesaurus)

There are recurrent cytogenetic aberrations: t(9;22)(q22;q12) and t(9;17)(q22;q11).

(Extraskeletal Myxoid Chondrosarcoma, NCI Thesaurus)

Chromosomal aberrations leading to rearrangement or elevated expression of the gene are a factor in a variety of leukemias.

(ETS1 wt Allele, NCI Thesaurus)

Ethyl methanesulfonate ethylates DNA, thereby damaging DNA and leading to genetic mutations, single-stranded breaks in DNA, and chromosomal aberrations.

(Ethyl Methanesulfonate, NCI Thesaurus)

Karyotype with at least three chromosomal aberrations.

(Complex Karyotype, NCI Thesaurus)

There is a recurrent cytogenetic aberration: t(11;22)(p13;q12).

(Desmoplastic small round cell tumor, NCI Thesaurus)

A chromosomal aberration involving this gene and the SLC45A3 gene may be associated with prostate cancer.

(ELK4 wt Allele, NCI Thesaurus)

Cytogenetic aberrations in the FANCM gene are both a cause of Fanconi anemia and a predisposing factor in the development of malignancies.

(FANCM wt Allele, NCI Thesaurus)

Further, chromosomal aberrations involving the gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

(FGFR1 wt Allele, NCI Thesaurus)