SULFONATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does sulfonate mean? 

• SULFONATE (noun)
  The noun SULFONATE has 1 sense:

1. a salt of sulphonic acid

  Familiarity information: SULFONATE used as a noun is very rare.

 Dictionary entry details 

• SULFONATE (noun)

Sense 1

Meaning:

A salt of sulphonic acid

Classified under:

Nouns denoting substances

Hypernyms ("sulfonate" is a kind of...):

salt (a compound formed by replacing hydrogen in an acid by a metal (or a radical that acts like a metal))

Hyponyms (each of the following is a kind of "sulfonate"):

alkylbenzenesulfonate (sulfonate of alkyl benzene)

 Context examples 

A cyclic sulfonate ester with potential antineoplastic activity.

(Cyclodisone, NCI Thesaurus)

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties.

(Busulfan, NCI Thesaurus)

A synthetic derivative of dithio-ethane sulfonate with uroprotective properties.

(Dimesna, NCI Thesaurus)

A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)

Methylene dimethane sulfonate alkylates DNA, resulting in interstrand DNA crosslinking, inhibition of DNA replication, disruption of the cell cycle, and cell death.

(Methylene Dimethane Sulfonate, NCI Thesaurus)

The sulfonate moiety releases hydrogen sulfide (H2S), which is involved, through an as of yet not fully elucidated mechanism of action, in the modulation of visceral perception and pain, possibly through the activation of ATP-sensitive potassium (KATP) ion channels and mu opioid receptors.

(Opioid Agonist GIC-1001, NCI Thesaurus)

Unlike other alkylating agents, benzaldehyde dimethane sulfonate has demonstrated antitumor activity in renal cell carcinoma.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)

Upon oral administration of GIC-1001, this agent may exert its therapeutic effects through the potential mechanisms of action for the trimebutine and sulfonate moieties: The trimebutine moiety can act as a motility enhancer in the gastrointestinal (GI) tract, as an antispasmodic agent to reduce colonic spasms, as an agonist of colonic mu and kappa opioid receptors, which could provide an analgesic effect, and blocks sodium channels and the release of a variety of GI peptides, which modulates the activity of visceral afferents.

(Opioid Agonist GIC-1001, NCI Thesaurus)

In addition, this agent is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the active carboxylic acid metabolite benzoic acid dimethane sulfonate (BA), which further contributes to its alkylating activity.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)

Although the exact mechanism of action has yet to be fully elucidated, benzaldehyde dimethane sulfonate alkylates DNA, which results in DNA double strand breaks, inhibition of DNA replication, cell cycle arrest and cell death.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)